Tokyo, Sept 20, 2006 (JCN) - GNI and its Chinese affiliate Shanghai Genomics announced September 15 that they have identified an important regulator and its associated signaling cascade in X-linked lymphoproliferative disease (XLP), a human immunological disorder.
XLP, also known as Duncan's syndrome, is an inherited genetic defect that causes immune system dysfunction in response to some viral infections. The disorder prevents patients from generating functional SAP proteins, which can subsequently cause a diverse range of immune system abnormalities and in many cases lead to the development of lymphoid tumors and fatality.
Due to the severe clinical manifestations found in XLP patients, intense efforts had recently focused on elucidating the signaling mechanism used by SAP to regulate in cells involved in immune surveillance against cancers.
The findings of the research are to be published by the Proceedings of the National Academy of Sciences of the United States of America (PNAS), one of the world's most-cited multidisciplinary scientific serials, during the week of September 11, 2006.
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